Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas.

Bone marrow involvement by lymphoma is considered a systemic dissemination of the disease arising elsewhere, although some tumors may arise primarily in the bone marrow microenvironment. Primary bone marrow lymphoma (PBML) is a rare entity whose real boundaries and clinicobiological significance are not well defined. Criteria to diagnose PBML encompass isolated bone marrow infiltration, with no evidence of nodal or extranodal involvement, including the bone, and the exclusion of leukemia/lymphomas that are considered to primarily involve the bone marrow. Twenty-one out of 40 lymphomas retrospectively reviewed by the International Extranodal Lymphoma Study Group from 12 institutions in 7 different countries over a 25-year period fulfilled the inclusion criteria. These cases comprised 4 follicular lymphomas (FLs), 15 diffuse large B-cell lymphomas (DLBCLs), and 2 peripheral T-cell lymphomas, not otherwise specified. The FL cases showed paratrabecular infiltration, BCL2 protein and CD10 expression, and BCL2 gene rearrangement. DLBCL showed nodular infiltration in 6 cases and was diffuse in 9 cases; it also showed positivity for BCL2 protein (9/10) and IRF4 (6/8). Median age was 65 years with male predominance. All but 3 FL patients were symptomatic. Most cases presented with cytopenias and high lactate dehydrogenase. Four patients (3 FL cases and 1 DLBCL case) had leukemic involvement. Most DLBCL patients received CHOP-like or R-CHOP-like regimens. The outcome was unfavorable, with a median overall survival of 1.8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy.

The presence of -308A TNFα is associated with anemia and thrombocytopenia in patients with myelodysplastic syndromes.

Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematological diseases characterized by refractory cytopenia(s). MDS patients show increased levels of tumor necrosis factor alpha (TNFα) which is a multifunctional proinflammatory cytokine. The aim of this work is to examine the presence of -308A/G TNFα variants and to analyze whether it is associated with clinical parameters in a cohort of 101 Argentinean de novo MDS patients. The A/A+A/G genotype at TNFα -308 was overrepresented 2-fold in our population (p=0.0499, odds ratio-OR: 2.107) and these differences were more evident in RA-FAB subtype (p=0.0424, OR: 2.502). The presence of the high expressing -308A allele was associated with lower hemoglobin level (8.3 vs 9.9g/dL; p=0.0206), reduced platelet counts (89,000 vs 130,000/µL; p=0.0381) and younger age (59 vs 68years; p=0.0122) at diagnosis. Also, these patients showed 3.8-fold higher risk of transfusion requirement (76% vs 46%, p=0.0105) during the follow up. In conclusion, the presence of an inherited -308A TNFα, which increases its transcription level, was associated with the MDS phenotype in our cohort of Argentine MDS patients. Also, an overexpression of TNFα may promote an underlying proinflammatory state that cooperates with intrinsic defects within MDS progenitors to increase the severity of certain phenotypic features of the disease.

[Population study of the prevalence of anaemia in the adult population of Buenos Aires, Argentina]. / Estudio poblacional de prevalencia de anemia en población adulta de Buenos Aires, Argentina.

OBJECTIVE: To determine the prevalence and causes of anaemia among adults in Buenos Aires, Argentina. DESIGN: Community-based, cross-sectional, quantitative study, with descriptive and analytic stages. SETTING: Study conducted in La Plata, Buenos Aires, Argentina. PARTICIPANTS: Rigorous selection from randomised sampling, with 3-stage stratification: geographical area, health aspects, and social/economic status. Adults >18 years old. RESULTS AND MAIN MEASUREMENTS: Social-economic and nutritional data and blood samples were obtained from each participant. If anaemia was detected, either treatment was given until complete recovery or further studies were conducted until definitive diagnosis was reached. Weight, height, haemoglobin, erythrocytes, haematocrit, transferrin, iron and ferritin levels, daily intake of calories, carbohydrates, lipids, proteins, calcium, iron, and vitamin C were measured. One thousand and thirty-six patients out of 1200 selected were analyzed. The prevalence of anemia in adults was 26.3%. Variables such as low social/economic status, nutritional questions, and frequency of doctor's consultation were associated with risk of anaemia. However, basic unsatisfied needs--a variable consisting of precarious housing and low educational level--, female sex, and living in slums were significant in the multivariate analysis (OR>2.5). CONCLUSIONS: One in 4 adults has anaemia, with iron deficiency as the major cause. Anaemia diagnosis is mainly associated with social and gender questions and the area of residence. This information, if used by the State to plan appropriate and focused preventive measures, could benefit not just adults but the entire community that depends on them.

Estudio poblacional de prevalencia de anemia en población adulta de Buenos Aires, Argentina / Population study of the prevalence of anaemia in the adult population of Buenos Aires, Argentina

Objetivo. Establecer la prevalencia de anemia en población adulta y determinar los factores asociados. Diseño. Estudio poblacional de corte transversal, con etapa descriptiva y analítica. Emplazamiento. Estudio realizado en La Plata, Argentina. Participantes. Muestra aleatoria, con estratificación trietápica considerando área geográfica, aspectos sanitarios y nivel socioeconómico de adultos mayores de 18 años. Resultados y mediciones principales. Encuestas socioeconómica y nutricional, estudios hematológico y sérico. A quienes se detectó anemia, se les aseguró un tratamiento completo o estudios ulteriores hasta el diagnóstico de certeza. Se valoró: peso y talla, hemoglobina, hematíes, hematocrito, ferremia, transferrina, ferritina, ingesta diaria de calorías, hidratos de carbono, lípidos, proteínas, calcio, hierro y vitamina C. Se analizó a 1.136 pacientes de los 1.200 seleccionados. La prevalencia de anemia en adultos fue del 26,3%. Numerosas variables, como nivel socioeconómico, aspectos nutricionales o frecuencia de consulta médica, se asocian al riesgo de anemia. Sin embargo, las necesidades básicas insatisfechas --variable compuesta por vivienda precaria y bajo nivel de instrucción--, sexo femenino y residencia en suburbios mantienen la significación en el análisis multivariable (odds ratio > 2,5). Conclusiones. Una de cada 4 personas adultas presenta anemia, y la ferropenia es la causa más importante. El diagnóstico de anemia se asoció, predominantemente, a aspectos sociales, el sexo o el área geográfica de residencia. Dicha información, utilizada por el Estado para planificar las medidas preventivas, oportunas y focalizadas, podrá lograr beneficios no sólo en los adultos, sino en toda la comunidad que depende económicamente de ellos

Objective. To determine the prevalence and causes of anaemia among adults in Buenos Aires, Argentina. Design. Community-based, cross-sectional, quantitative study, with descriptive and analytic stages. Setting. Study conducted in La Plata, Buenos Aires, Argentina. Participants. Rigorous selection from randomised sampling, with 3-stage stratification: geographical area, health aspects, and social/economic status. Adults >18 years old. Results and main measurements. Social-economic and nutritional data and blood samples were obtained from each participant. If anaemia was detected, either treatment was given until complete recovery or further studies were conducted until definitive diagnosis was reached. Weight, height, haemoglobin, erythrocytes, haematocrit, transferrin, iron and ferritin levels, daily intake of calories, carbohydrates, lipids, proteins, calcium, iron, and vitamin C were measured. One thousand and thirty-six patients out of 1200 selected were analyzed. The prevalence of anemia in adults was 26.3%. Variables such as low social/economic status, nutritional questions, and frequency of doctor's consultation were associated with risk of anaemia. However, basic unsatisfied needs--a variable consisting of precarious housing and low educational level--, female sex, and living in slums were significant in the multivariate analysis (OR>2.5). Conclusions. One in 4 adults has anaemia, with iron deficiency as the major cause. Anaemia diagnosis is mainly associated with social and gender questions and the area of residence. This information, if used by the State to plan appropriate and focused preventive measures, could benefit not just adults but the entire community that depends on them